Objective vs Subjective

The use of low doses of quetiapine for insomnia, while common, is not recommended; there is little evidence of benefit and concerns regarding adverse effects.[31][32][33][34][35][36] https://en.wikipedia.org/wiki/Quetiapine

双相诊断严谨化

(1) 双相就是要有明显的躁狂发作才行 , 而且很多人平常就是工作狂想法快 , 人格基础不好 , 那些喜欢诊断双相的医生就是看不得别人好 , 什么人只要稍微好一点就非得要算混合双相是重性精神病 , 诊断一定要非常谨慎才行 , 你说这些人十年以内躁狂迟早会发 , 那也要等到躁狂发作才能诊断啊 , ** 你们什么病人一上来就给人家心境稳定剂 + 二代抗精神病药 , 这对青少年的发育影响大啊 , 对生活影响大啊 ** , 而且这些人在我看来，大部分使用抗抑郁药辅助苯二氮卓类都能治好啊，实在不行加点 ** 小剂量喹硫平 **

(2) 喜欢诊断双相的精神科医生们 , 你们真会区分双相混合和抑郁焦虑吗 , 很多人只是比较焦虑而已 , 所以就比较激越 , 话比较多 , 你那里看出来他们又混合躁狂的特征 ? ... 他们想法多是因为他们焦虑过度担心啊

https://www.zhihu.com/question/320953626/answer/658444013

https://www.spectrumnews.org/features/deep-dive/the-lost-girls/ > It took 10 years, 14 psychiatrists, 17 medications and 9 diagnoses before someone finally realized that what Maya has is autism. Maya loves numbers, and with her impeccable memory, she can rattle off these stats: that the very first psychiatrist she saw later lost his right to practice because he slept with his patients. That psychiatrist No. 12 met with her for all of seven minutes and sent her out with no answers. That during her second year at Cambridge University in the U.K., industrial doses of the ** antipsychotic quetiapine ** led her to pack on more than 40 pounds and sleep 17 hours a day. (Maya requested that her last name not be used.)

全世界精神科都喜欢开 quetiapine

The suicide rate for people with bipolar disorder is 15 times higher than in the general population, according to the diagnostic manual used by American psychiatrists. Nonetheless, bipolar disorder has received “relatively little attention” in autism research articles, compared to other conditions, autism researchers wrote in the International Review of Psychiatry. https://sparkforautism.org/discover_article/autism-bipolar-disorder/

「媒体」「公众」只关注「高功能」「天才病」

抑郁症诊断严谨化

( 1 ) 基于生物导向 , 抑郁症是一种生理的 , 自身免疫的疾病 , 一个人无缘无故就是因为自身免疫的启动导致了脑功能的异常 , 得了这种病伴随着反复发作 , 认知功能退化 , 给社会和患者带来很大的负担区别于那些受了生活打击的丧亲的躯体形式作为突出特点有癔症色彩 ( ? 我没理解这句 )

( 3 ) 抑郁症和双相都是全身性的病变 , 这些病变会影响情绪 , 出现精神症状 , 也会影响凝血功能 , 心血管 , 肌肉 , 久了必然会导致全身性的组织损伤和功能受损 , 反过来说 , 光是情绪不好或是情绪波动大 , 有了这些精神症状也并不能诊断这些疾病

( 4 ) 很多吃了很久的药物效果不佳的患者，应该再反思回来，是不是这个药并不能改善患者的问题，因此患者可能并不是在这个相应诊断所对应的病理生理机制上出现了障碍

https://www.mayoclinic.org/zh-hans/diseases-conditions/migraine-headache/expert-answers/migraines/faq-20058268

https://www.theguardian.com/lifeandstyle/2015/jan/04/depression-allergic-reaction-inflammation-immune-system

https://zhuanlan.zhihu.com/p/560527742

https://www.moleculera.com/is-autism-an-autoimmune-disorder/ > One study found that a majority of patients with autism spectrum disorder had elevated levels of autoantibodies directed against brain tissue.

睾酮本身就是免疫抑制剂

https://m.thepaper.cn/newsDetail_forward_1967183

https://www.mayoclinic.org/zh-hans/steroids/art-20045692

女性更容易有 autoimmune 现代男性睾酮降低 ( 相较狩猎时期 ) 才容易过敏 ( –> 空间能力数学发展 ) male with lower T & female with higher T

Mogil 团队 2017 年发表论文称妊娠早期 , 小鼠会从典型的女性非小胶质细胞依赖性疼痛致敏机制转变为涉及 小胶质细胞 的男性相关机制 https://zhuanlan.zhihu.com/p/62463201

母亲的免疫系统不能攻击到胎儿 , 即便后者从基因的层面不同于她自己的身体 , 因此 , 怀孕对免疫力产生了一系列改变 , 其中一些会 抑制母亲的免疫系统 , 使她更易于被被一些感染病侵袭 , 例如新冠病毒和水痘男性似乎没有如此灵活的免疫系统但女性为了保护胎儿所具有的免疫的灵活性 , 却要以女性的大脑为代价 https://zhuanlan.zhihu.com/p/548303239

只有现代女性演化出来「牺牲道德」sexual morality 纠缠「智慧之果」( 农耕 , 再进入工业资本社会 ) , 非人哺乳动物雌性就没有月经 , 雌性控制营养输出 , 资源不够可以杀了幼仔 , 生一个幼仔不费资源

养一个数学天才温室提供双倍能量 & 知识爆炸培养周期漫长

Feb 14, 2025

Insomnia in school-age children with Asperger syndrome or high-functioning autism https://pubmed.ncbi.nlm.nih.gov/16646974/

https://www.reddit.com/r/aspergers/comments/17hkt09/insomnia_is_a_primary_characteristic_of_autism/

https://www.thetransmitter.org/spectrum/sleep-problems-autism-explained/